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Search results “Chromatin and transcription regulation”
DNA and chromatin regulation | Biomolecules | MCAT | Khan Academy
 
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Created by Tracy Kim Kovach. Watch the next lesson: https://www.khanacademy.org/test-prep/mcat/biomolecules/gene-control/v/regulation-of-transcription?utm_source=YT&utm_medium=Desc&utm_campaign=mcat Missed the previous lesson? https://www.khanacademy.org/test-prep/mcat/biomolecules/gene-control/v/jacob-monod-the-lac-operon?utm_source=YT&utm_medium=Desc&utm_campaign=mcat MCAT on Khan Academy: Go ahead and practice some passage-based questions! About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s MCAT channel: https://www.youtube.com/channel/UCDkK5wqSuwDlJ3_nl3rgdiQ?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Views: 114421 khanacademymedicine
Transcription Regulation via Histone Modifications
 
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Welcome! Through this video I hope to explain some mystifying concepts about nucleosomes, and how these eight-part microscopic proteins help control the wide variety of life we see today through regulation of transcription.
Views: 2785 Sarah Montalbano
DNA and Chromatin Regulation
 
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Learn about the various ways that the transcription of DNA is regulated.
Views: 2000 Tracy Kovach
Regulation of transcription | Biomolecules | MCAT | Khan Academy
 
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Created by Tracy Kim Kovach. Watch the next lesson: https://www.khanacademy.org/test-prep/mcat/biomolecules/gene-control/v/post-translational-regulation?utm_source=YT&utm_medium=Desc&utm_campaign=mcat Missed the previous lesson? https://www.khanacademy.org/test-prep/mcat/biomolecules/gene-control/v/dna-and-chromatin-regulation?utm_source=YT&utm_medium=Desc&utm_campaign=mcat MCAT on Khan Academy: Go ahead and practice some passage-based questions! About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s MCAT channel: https://www.youtube.com/channel/UCDkK5wqSuwDlJ3_nl3rgdiQ?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Views: 256431 khanacademymedicine
Regulation of Gene Expression: Operons, Epigenetics, and Transcription Factors
 
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We learned about gene expression in biochemistry, which is comprised of transcription and translation, and referred to as the "central dogma" of molecular biology. But how is this process regulated? How does a cell know which genes to express and when? Well it's pretty complicated, but let's just get our feet wet by looking at operons, epigenetics, and transcription factors! Subscribe: http://bit.ly/ProfDaveSubscribe [email protected] http://patreon.com/ProfessorDaveExplains http://professordaveexplains.com http://facebook.com/ProfessorDaveExpl... http://twitter.com/DaveExplains Biology Tutorials: http://bit.ly/ProfDaveBio Biochemistry Tutorials: http://bit.ly/ProfDaveBiochem General Chemistry Tutorials: http://bit.ly/ProfDaveGenChem Organic Chemistry Tutorials: http://bit.ly/ProfDaveOrgChem Classical Physics Tutorials: http://bit.ly/ProfDavePhysics1 Modern Physics Tutorials: http://bit.ly/ProfDavePhysics2 Mathematics Tutorials: http://bit.ly/ProfDaveMaths American History Tutorials: http://bit.ly/ProfDaveAmericanHistory
Views: 103205 Professor Dave Explains
The role of chromatin structure and regulation of transcription
 
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Subject :Bioinformatics Course :2nd Year / Semester III Keyword : SWAYAMPRABHA
Chromatin, Histones and Modifications, Rate My Science
 
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http://ratemyscience.com/ Publish and rate science Cathepsin L as a protease responsible for proteolytically processing the N-terminal H3 tail. Cell. 2008 Oct 17;135(2):284-94. Chromatin is the complex basis of DNA and protein that makes up chromosomes. Changes in chromatin structure are affected by chemical modifications of histone proteins such as methylation (DNA and proteins) and acetylation (proteins), and by non-histone, DNA-binding proteins.
Views: 587373 kosigrim
DNA Structure- Chromatin
 
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We can think of chromatin as the packaging material in which we keep our DNA. Chromatin is a structure made up of DNA, RNA and proteins and it's regulation effects how our cells express their genes. In this tutorial we will talk about it's basic structure, components and functions.
Views: 41341 Medic Tutorials
Histone acetylation and methylation
 
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This epigenetics lecture explains about the Histone acetylation and methylation. Histone acetylation and deacetylation are the approaches in which the lysine residues within the N-terminal tail protruding from the histone core of the nucleosome are acetylated and deacetylated as part of gene law. Histone acetylation and deacetylation are most important components of gene regulation. These reactions are normally catalysed through enzymes with "histone acetyltransferase" (HAT) or "histone deacetylase" (HDAC) endeavor. Acetylation is the approach the place an acetyl sensible crew is transferred from one molecule (on this case, Acetyl-Coenzyme A) to an extra. Deacetylation is readily the reverse response the place an acetyl staff is removed from a molecule. Acetylated histones, octameric proteins that organize chromatin into nucleosomes and finally better order constructions, symbolize a sort of epigenetic marker inside chromatin. Acetylation removes the positive charge on the histones, thereby reducing the interaction of the N termini of histones with the negatively charged phosphate companies of DNA. As a consequence, the condensed chromatin is modified into a more comfortable constitution that's related to higher levels of gene transcription. This leisure can also be reversed by way of HDAC pastime. Comfortable, transcriptionally active DNA is known as euchromatin. More condensed (tightly packed) DNA is referred to as heterochromatin. Condensation will also be brought on via techniques together with deacetylation and methylation; the action of methylation is oblique and has no outcomes upon charge. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching
Views: 84454 Shomu's Biology
Eukaryotic Gene Expression/Chromatin Modification
 
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This video takes a close look at the stage of eukaryotic gene expression known as chromatin modification.
Views: 2431 Ray Cinti
DNA Packaging Animation | chromatin, histone and nucleosome modifications
 
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DNA Packaging Animation | chromatin, histone and nucleosome modifications - This animation will explain the DNA packaging mechanism and the role of histone proteins in condensing chromatin into nucleosome structure. transcript available below- 1st to develop and function properly it must rely on the white jeans of the White House in most of the genes in eukaryotes are located in the nucleus within a tangled material called chromatin researchers are beginning to discover that the structure of chromatin dictates whether or not a gene can be transcribed most of the chromatin in a cell's nucleus is highly ordered and tightly coiled in chromatin DNA is wrapped around several types of proteins called histones each of the many coil units is a nucleosome the histone proteins have an overall positive charge and the DNA has a negative charge these opposite charges attract forming a tight association between the protein and the DNA in this chromatin structure the DNA of the gene is virtually inaccessible and RNA polymerase cannot transcribe it if the DNA is inaccessible is a turnover gene are actually many different triggers for initiating transcription as one example is cell may receive a signal during development that result in the activation or production of the specific title protein called a regular Tory transcription factor the regular Tory transcription factor recognises and binds to exposed sequences in the chromatin of a specific gene is made and work in conjunction with a set of proteins that can change the chromatin structure for example chromatin remodelling may occurred to the function of a title protein called a chromatin remodelling complex the action of this complex is not well understood but the resulting structural changes he exposed regulatory sequences in the DNA of the regulatory sequences may be close or thousands of nucleotides away from the transcription region of the gene for simplicity will examine the naked DNA of the gene about 30 nucleotides upstream of the transcription region is the promoter the core regular Tory sequence of the gene next to the promoter lies the promoter proximal and at promoter proximal elements stimulate transcription through the binding of tissue-specific regulatory transcription factors enhancers are regular Tory sequences that may lie thousands of nucleotides from the transcription start site tissue-specific regulatory transcription factors bind to enhancers to stimulate transcription when regular Tory transcription factors are bound to DNA in Iraq with other transcription factors these basal transcription factors bind to promoters they are required for transcription to occur but they are not cell specific and do not provide much in the way of regulation when all the diesel transcription factors are bound they form a basal transcription complex one of the diesel transcription factors called a total binding protein TDP binds to a specific sequence known as at OtterBox within the promoter batata binding protein allows RNA polymerase to contact DNA the basal transcription complex then recruits RNA polymerase and transcription begins in cell types are lacking the tissue-specific regulatory transcription factors this particular gene would not be transcribed. Thank you for watching DNA packaging animation video. Thank You for watching our videos from Biology Animation Videos channel. This channel is created to compile animated biology lectures and videos from different animation sources. None of these videos are created by us. we just organize them and place them in YouTube for your understanding so If you want to know details about these animation please see the credit section for knowing the original content developer and please convey privilege and gratitude to them. Thank You. Our website- https://www.biologyanimationvideos.weebly.com
Regulated Transcription
 
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NDSU Virtual Cell Animations Project animation "Regulated Transcription". For more information please see http://vcell.ndsu.edu/animations. Gene expression is controlled in many different ways. When proteins from outside a cell signal for a specific gene to be transcribed, it is known as regulated transcription. This animation illustrates how a protein like insulin can trigger a regulated transcription event, in addition to setting off the signal pathway illustrated in our Insulin Signaling video.
Views: 242142 ndsuvirtualcell
How Genes are Regulated: Transcription Factors
 
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Like us on Facebook: https://www.facebook.com/pages/Stroma-Studios/290868104261105?sk=wall Each cell in our body inherits the same master copy of DNA, but different cell types use it differently. Transcription Factors help influence which genes are used in which cell. Understanding how these dynamic proteins physically interact with DNA allows us to better understand and model their binding to DNA and their regulation of gene expression. Scientific Direction by the Wasserman Lab at the University of British Columbia: http://www.cmmt.ubc.ca/research/investigators/wasserman/lab Animation and editing by Blair Lyons of Stroma Studios: http://www.stromastudios.com
Views: 309888 Blair Lyons
H Chen: Towards a 4D understanding of chromatin architecture and transcriptional regulation.
 
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"Hongtao Chen (Princeton University) presents 'Towards a 4D understanding of chromatin architecture and transcriptional regulation.' A presentation at the 'Regulation of Gene Expression I ' session of the Annual Drosophila Research Conference at The Allied Genetics Conference, July 13-17, 2016, Orlando, Florida. Read the abstract: http://www.genetics-gsa.org/genetics/2016/full_abstracts/166512019.htm For more presentations from #TAGC16 visit: http://www.genetics-gsa.org/tagcvideos or browse the playlists at: https://www.youtube.com/user/GeneticsSociety/playlists More on #TAGC16: http://www.genetics2016.org/ More on GSA: http://www.genetics-gsa.org/ More on genetics at the GSA blog Genes to Genomes: http://genestogenomes.org
Chromatin remodeling
 
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This video explains the mechanism of chromatin remodeling using chromatin remodeling complex proteins like HAT and HDAC etc. For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html PPT source- Dr. Anindita Banerjee, Department of Microbiology, St. Xavier's college
Views: 20577 Shomu's Biology
The 3D genome organization and long-range control of gene expression
 
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The 3D genome organization and long-range control of gene expression Air date: Wednesday, February 03, 2016, 3:00:00 PM Category: WALS - Wednesday Afternoon Lectures Runtime: 01:00:35 Description: NIH Director’s Wednesday Afternoon Lecture Series The 3-dimensional (3D) genome organization plays an essential role in orchestrating many essential nuclear processes, including DNA replication, transcription, and repair of DNA damages. Great strides have been made recently in the study of 3D chromatin architecture in mammalian cells, with the development of technologies for genome-wide analysis of chromatin interactions at increasing precision and concepts such as "chromosome territories," "topologically associating domains," and "chromatin loops". For his lecture, Dr. Ren will discuss how these advances are transforming the study of gene regulatory mechanisms in mammalian cells. He will give specific examples that illustrate the role of 3D chromatin organization in developing revolutionary tools in sequencing diploid genomes; elucidate the molecular basis of genetic disorders caused by genome structural variations; and offer a functional characterization of enhancers, a class of gene regulatory sequences that can activate target genes at a large genomic distance. The dysfunction of enhancers has been implicated in the etiology of cancer, diabetes, and a broad spectrum of other human diseases. For more information go to https://oir.nih.gov/wals Author: Bing Ren, Ph.D., Ludwig Institute for Cancer Research, University of California, San Diego Permanent link: http://videocast.nih.gov/launch.asp?19464
Views: 6901 nihvcast
Gene Regulation
 
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031 - Gene Regulation Paul Andersen explains how genes are regulated in both prokaryotes and eukaryotes. He begins with a description of the lac and trp operon and how they are used by bacteria in both positive and negative response. He also explains the importance of transcription factors in eukaryotic gene expression. Do you speak another language? Help me translate my videos: http://www.bozemanscience.com/translations/ All of the images are licensed under creative commons and public domain licensing: Bioinformatik, English: Jawahar Swaminathan and MSD staff at the European Bioinformatics InstituteDeutsch: Jawahar Swaminathan und MSD Mitarbeiter am Europäischen Institut für BioinformatikPlattdüütsch: Jawahar Swaminathan un de Lüüd von MSD an dat Europääsche Institut för. English: Cartoon Representation of the Molecular Structure of Protein Registered with 2nvw Code., [object HTMLTableCellElement]. English: http://www.ebi.ac.uk/pdbe-srv/view/images/entry/2nvw600.png, displayed on http://www.ebi.ac.uk/pdbe-srv/view/entry/2nvw/summary. http://commons.wikimedia.org/wiki/File:PDB_2nvw_EBI.jpg. DNA, n.d. http://openclipart.org/detail/58543/dna-by-kumar35885. "File:E Coli at 10000x, Original.jpg." Wikipedia, the Free Encyclopedia, November 13, 2013. http://en.wikipedia.org/w/index.php?title=File:E_coli_at_10000x,_original.jpg&oldid=478393073. "File:Glass of Milk on Tablecloth.jpg." Wikipedia, the Free Encyclopedia. Accessed December 1, 2013. http://en.wikipedia.org/wiki/File:Glass_of_milk_on_tablecloth.jpg. "File:Lac operon1.png." Wikipedia, the Free Encyclopedia. Accessed December 1, 2013. http://en.wikipedia.org/wiki/File:Lac_operon1.png. "File:Protein TBP PDB 1c9b.png." Wikipedia, the Free Encyclopedia. Accessed December 1, 2013. http://en.wikipedia.org/wiki/File:Protein_TBP_PDB_1c9b.png. "File:Ribosome mRNA Translation En.svg." Wikipedia, the Free Encyclopedia. Accessed December 1, 2013. http://en.wikipedia.org/wiki/File:Ribosome_mRNA_translation_en.svg. Forluvoft. Simple Cartoon of Transcription Termination, October 9, 2007. Own work. http://commons.wikimedia.org/wiki/File:Simple_transcription_termination1.svg. Intro Music Atribution Title: I4dsong_loop_main.wav Artist: CosmicD Link to sound: http://www.freesound.org/people/CosmicD/sounds/72556/ Creative Commons Atribution License
Views: 1160069 Bozeman Science
Nir Friedman Hebrew University - Genes Chromatin and Transcription - Technion lecture
 
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Nir Friedman of Hebrew University, Technion lecture - Genes, Chromatin and Transcription A central question in molecular biology is understanding how cells process information and decide how to react. A crucial level of regulation is on gene transcription, the first step in producing the protein that the gene encodes. Transcriptional regulation is crucial for defining the cell's identity and its ability to function. The main dogma is that regulatory "instructions" are part of the genetic blueprint encoded in the genome, the sequence of DNA base-pairs. In recent years there is growing evidence for additional layers of information that are passed from a cell to its daughter cells not through the DNA sequence. One of these layers is chromatin, the protein-DNA complex that forms chromosomes. The basic unit of chromatin is a nucleosome, around which about ~150 base pairs of DNA are wound. Each nucleosome can be modified by addition of multiple discrete marks, which in turn can be recognized by specific regulatory proteins that modify nucleosomes or impact transcription. As such nucleosomes serve as a substrate for recording information by regulatory elements and reading it by others, and for passing information to daughter cells following cell division. These new discoveries raise basic questions of what does chromatin state encodes, how it is maintained, updated, passed to next generations, and how it interact with transcription. The research to answer these questions relies on new methodologies that collect massive amount of data about chromatin state in each location along the genome. In this talk I will provide an overview of the field and describe ongoing investigations that attempt to answer these questions.
Views: 592 Technion
Gene regulation in eukaryotes
 
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Gene regulation in eukaryotes - This lecture explains about the eukaryotic gene regulation. Regulation of gene expression entails a vast variety of mechanisms which can be utilized by cells to expand or shrink the creation of particular gene products (protein or RNA), and is informally termed gene legislation. Subtle packages of gene expression are greatly found in biology, for illustration to set off developmental pathways, reply to environmental stimuli, or adapt to new food sources. Virtually any step of gene expression can also be modulated, from transcriptional initiation, to RNA processing, and to the post-translational change of a protein. Gene regulation is main for viruses, prokaryotes and eukaryotes because it raises the flexibility and adaptability of an organism via permitting the cellphone to specific protein when needed. Although as early as 1951 Barbara McClintock confirmed interaction between two genetic loci, Activator (Ac) and Dissociator (Ds), in the color formation of maize seeds, the first discovery of a gene law approach is widely regarded to be the identification in 1961 of the lac operon, learned through Jacques Monod, in which some enzymes involved in lactose metabolism are expressed by using the genome of E. Coli handiest within the presence of lactose and absence of glucose. Furthermore, in multicellular organisms, gene regulation drives the processes of cellular differentiation and morphogenesis, main to the creation of unique cellphone forms that possess different gene expression profiles, and therefore produce one of a kind proteins/have special ultrastructures that suit them to their capabilities (although they all possess the genotype, which follows the equal genome sequence). The initiating event main to a transformation in gene expression include activation or deactivation of receptors. Additionally, there's proof that alterations in a mobile's option of catabolism results in altered gene expressions. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching
Views: 146492 Shomu's Biology
Gene Regulation in Eukaryotes
 
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Donate here: http://www.aklectures.com/donate.php Website video link: http://www.aklectures.com/lecture/gene-regulation-in-eukaryotes Facebook link: https://www.facebook.com/aklectures Website link: http://www.aklectures.com
Views: 127792 AK LECTURES
Prof. Nir Friedman -"Dynamics of Chromatin and Transcription"
 
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Prof. Nir Friedman from the Hebrew University gave a lecture on on "Dynamics of Chromatin and Transcription" on March 14, as part of the 2012 workshop on Control Theory in Biology, within the framework of The Stephen and Sharon Seiden Frontiers in Science and Engineering Forum
Views: 565 Technion
Chromatin Remodeling in Eukaryotes
 
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Moof's Medical Biochemistry Video Course: http://moof-university.thinkific.com/courses/medical-biochemistry-for-usmle-step-1-exam
Views: 45324 Moof University
Gene insulators
 
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This tutorial about DNA methylation explains what are gene insulators and what is its importance in genomic imprinting. It also deals with differential expression of eukaryotic gene. For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html PPT source- Dr. Anindita Banerjee, Department of Microbiology, St. Xavier's college
Views: 5416 Shomu's Biology
Gene regulation in prokaryotes
 
07:05
This lecture explains about the Gene regulation in prokaryotes. Regulation of gene expression entails a broad range of mechanisms that are used by cells to develop or diminish the production of specific gene products (protein or RNA), and is informally termed gene legislation. Subtle applications of gene expression are greatly located in biology, for example to trigger developmental pathways, respond to environmental stimuli, or adapt to new food sources. Practically any step of gene expression may also be modulated, from transcriptional initiation, to RNA processing, and to the put up-translational amendment of a protein. Gene law is main for viruses, prokaryotes and eukaryotes as it raises the flexibility and suppleness of an organism via allowing the mobile to express protein when wanted. Despite the fact that as early as 1951 Barbara McClintock confirmed interplay between two genetic loci, Activator (Ac) and Dissociator (Ds), within the color formation of maize seeds, the primary discovery of a gene legislation procedure is largely regarded to be the identification in 1961 of the lac operon, learned by means of Jacques Monod, where some enzymes concerned in lactose metabolism are expressed with the aid of the genome of E. Coli most effective in the presence of lactose and absence of glucose. Furthermore, in multicellular organisms, gene legislation drives the approaches of mobile differentiation and morphogenesis, leading to the creation of specific mobilephone types that possess distinct gene expression profiles, and as a consequence produce distinctive proteins/have different ultrastructures that swimsuit them to their features (though all of them possess the genotype, which follows the equal genome sequence). The initiating event leading to a change in gene expression comprise activation or deactivation of receptors. Also, there may be evidence that alterations in a cell's choice of catabolism results in altered gene expressions. For more information, log on to- http://www.shomusbiology.com/ Get Shomu's Biology DVD set here- http://www.shomusbiology.com/dvd-store/ Download the study materials here- http://shomusbiology.com/bio-materials.html Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology- Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store Shomu’s Biology assignment services – www.shomusbiology.com/assignment -help Join Online coaching for CSIR NET exam – www.shomusbiology.com/net-coaching We are social. Find us on different sites here- Our Website – www.shomusbiology.com Facebook page- https://www.facebook.com/ShomusBiology/ Twitter - https://twitter.com/shomusbiology SlideShare- www.slideshare.net/shomusbiology Google plus- https://plus.google.com/113648584982732129198 LinkedIn - https://www.linkedin.com/in/suman-bhattacharjee-2a051661 Youtube- https://www.youtube.com/user/TheFunsuman Thank you for watching
Views: 88767 Shomu's Biology
Roger Kornberg, “Unexpected Role of Chromatin in Transcription”
 
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Presentation by Dr. Roger Kornberg at the Sidney Altman Symposium held on March 24, 2016 at the Greenberg Center, Yale University.
Views: 1303 YaleUniversity
Mod-03 Lec-10 Chromatin remodelling & gene regulation
 
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Eukaryotic Gene Expression:Basics & Benefits by Prof.P N RANGARAJAN,Department of Biochemistry,IISC Bangalore. For more details on NPTEL visit http://nptel.iitm.ac.in
Views: 4239 nptelhrd
Enhancer regulation of transcriptional bursting parameters revealed by forced chromatin looping
 
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Enhancer regulation of transcriptional bursting parameters revealed by forced chromatin looping
Views: 1851 Arjun Raj
Transcription Factors & Promoter Region.
 
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Watch 800+ Medical Lectures at https://www.DrNajeebLectures.com ─────────────── DR. NAJEEB LECTURES ─────────────── Dr. Najeeb Lectures are the World's Most Popular Medical Lectures. Over 1 Million+ students from 190 countries trust Dr. Najeeb Lectures to Master Medical Sciences. Sign up for a membership plan on our website and access 800+ videos on Basic Medical Sciences & Clinical Medicine. ───────────────── OUR YOUTUBE CHANNEL ───────────────── Here on YouTube, we only upload free sample videos. Most of them are teaser videos (not complete lectures). If you like these videos you can check out our entire video library on our website at https://www.DrNajeebLectures.com. ────────────────────── WHY SIGN UP FOR MEMBERSHIP? ────────────────────── ► 800+ Medical Lectures. ► Basic Medical Sciences. ► Clinical Medicine. ► New videos every week in HD. ► Download videos for offline access. ► Fast video playback (0.5x - 2x) ► Watch videos on any device. ► Fanatic customer support. ► Trusted by 1 Million+ students. Learn more at https://www.DrNajeebLectures.com
Views: 14817 Dr. Najeeb Lectures
Transcription Regulation
 
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Learn about the dynamics and stochastics of transcription regulation! Animated in Maya by undergraduate students at CU Boulder. More information at dowell.colorado.edu
Views: 13277 flamingmanzana
Throwing Transcription for a Loop: The Role of Chromatin Insulators in the 3D Nucleus
 
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Air date: Wednesday, December 14, 2011, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local Category: Wednesday Afternoon Lectures Description: Interactions among regulatory sequences such as enhancers, promoters and insulators give rise to a three-dimensional structure of the genetic material in the eukaryotic nucleus. We have used 5C and HiC to determine the nature of inter- and intra-chromosomal interactions in the Drosophila genome. The results suggest that each chromosome arm is an independent physical unit in terms of its interactions with the rest of the genome. Each chromosome folds into modules with a hierarchical organization. These modules comprise 80% of the genome, they are composed of different types of chromatin, they have a low gene density, and the genes are expressed at low levels, independent of their chromatin composition. Chromosome modules are separated by inter-module regions that comprise 20% of the genome. Inter-module regions have high gene density and comprise different chromatin types, but genes are expressed at higher levels than in chromosome modules. Inter-chromosome modules contain insulator proteins, which, together with RNA polymerase II, mediate interactions with other inter-chromosome modules. Chromosome modules also interact with each other but these interactions are not enriched in any known proteins. We are attempting to deconstruct this 3D structure into specific classes of interactions and determine their role in gene expression. In addition, we are exploring mechanisms by which organization can be regulated. In particular, parylation of insulator proteins appears to regulate interactions among these proteins and the establishment of a specific three-dimensional organization of the chromatin. The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. Author: Dr. Victor Corces, Emory University Runtime: 01:05:56 Permanent link: http://videocast.nih.gov/launch.asp?17027
Views: 7220 nihvcast
Types of chromatin remodeling
 
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This tutorial about chromatin remodeling explains different types of chromatin remodeling complexes and their importance in eukaryotic transcription. For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html PPT source- Dr. Anindita Banerjee, Department of Microbiology, St. Xavier's college
Views: 5377 Shomu's Biology
Epigenetics Overview
 
02:15
Brief introduction to epigenetic regulation including the the two states of chromatin: euchromatin and heterochromatin. Transcript Epigenetic regulation encompasses a number of different modifications to chromatin. These include methylation of the DNA on cytosine bases, a modification that can further be oxidized, as well as modification of the histone tails that emanate from the core of the nucleosome. The tails of core histones labeled here can be altered with distinct chemical modifications including methylation of Histone H3, acetylation of Histone H4, and phosphorylation of Histone H2B. Euchromatin is often characterized by a more open and accessible state of the DNA one in which transcription factors have access to their cognate binding sites and can therefore recruit enzymes like histone acetyl transferases that acetylate histone tails and activate genes by recruiting components of the basal transcriptional machinery, including RNA polymerase. Heterochromatin ,in contrast, is thought to be characterized by a more repressive tight bundling of nucleosomes which impedes transcription factors from gaining access to regulatory sites on the DNA. Methylation of cytosine bases and regions called CpG Islands is a hallmark of transcriptionally repressed heterochromatin. These methylated cytosines in turn recruit proteins like MeCP2 (Methyl CpG binding protein 2) and HP1 (Heterochromatin Protein 1). These proteins are thought to maintain a repressive state of chromatin by inducing histone deacetylation by HDACs as well as histone tail methylation by histone methyltransferase enzymes.
DNA Binding motifs overview
 
06:58
This video describes several DNA binding motifs present in wide variety of Transcription factors and also describes how they interact with DNA with proper examples
Views: 4383 Arpan Parichha
Transcriptional Regulation in Plant Genomes
 
19:07
This is a presentation from the Inaugural Botanical Research Symposium & Celebration organized by the Emory University Herbarium held on September 21, 2018 in Atlanta, GA, USA. Transcriptional Regulation in Plant Genomes Roger Deal, PhD The transcriptional regulatory structure of plant genomes remains poorly defined relative to animals. It is unclear how many cis-regulatory elements exist, where these elements lie relative to promoters, and how these features are conserved across plant species. We employed the Assay for Transposase-Accessible Chromatin (ATAC-seq) in four plant species (Arabidopsis thaliana, Medicago truncatula, Solanum lycopersicum, and Oryza sativa) to delineate accessible chromatin regions and transcription factor (TF) binding sites across each genome. Despite 10-fold variation in intergenic space among species, the majority of accessible chromatin regions lie within 3 kilobases upstream of a transcription start site in all species. Additionally, we found a common set of four TFs that appear to regulate conserved gene sets in the root tips of all four species, suggesting that TF-gene networks are generally conserved. These analyses revealed common regulatory principles among plant species as well as fundamental differences between plants and animals.
Views: 0 TeachEthnobotany
Transcription factors
 
21:48
This video will explain the structure and role of transcription factors of eukaryotic cells and how they facilitates the gene transcription process. For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html
Views: 31397 Shomu's Biology
Post-transcriptional regulation | Biomolecules | MCAT | Khan Academy
 
06:08
Created by Tracy Kim Kovach. Watch the next lesson: https://www.khanacademy.org/test-prep/mcat/biomolecules/gene-control/v/non-coding-rna-ncrna?utm_source=YT&utm_medium=Desc&utm_campaign=mcat Missed the previous lesson? https://www.khanacademy.org/test-prep/mcat/biomolecules/gene-control/v/regulation-of-transcription?utm_source=YT&utm_medium=Desc&utm_campaign=mcat MCAT on Khan Academy: Go ahead and practice some passage-based questions! About Khan Academy: Khan Academy offers practice exercises, instructional videos, and a personalized learning dashboard that empower learners to study at their own pace in and outside of the classroom. We tackle math, science, computer programming, history, art history, economics, and more. Our math missions guide learners from kindergarten to calculus using state-of-the-art, adaptive technology that identifies strengths and learning gaps. We've also partnered with institutions like NASA, The Museum of Modern Art, The California Academy of Sciences, and MIT to offer specialized content. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s MCAT channel: https://www.youtube.com/channel/UCDkK5wqSuwDlJ3_nl3rgdiQ?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Views: 128115 khanacademymedicine
Epigenetics
 
09:29
Hank & his clone Circus Hank explain the power of epigenetics, which studies the factors that determine how much or whether some genes are expressed in your body. Like SciShow on Facebook! http://www.facebook.com/scishow Follow SciShow on Twitter! http://www.twitter.com/scishow More SciShow! Solar Energy - http://youtu.be/4uPVZUTLAvA Foldit Gamers FTW - http://youtu.be/JdBcpdH_ptA
Views: 1839751 SciShow
Nucleosome Remodeling
 
09:54
This lecture explains about the nucleosome remodeling by nucleosome remodeling complex using dna methylation or histone acetylation and deacetylation. For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html Eukaryotic genomes are ubiquitously associated into chromatin; however, cells must spatially and temporally regulate specific loci independently of bulk chromatin. In order to achieve the high level of control required to co-ordinate nuclear processes such as DNA replication, repair, and transcription, cells have developed a variety of means to locally and specifically modulate chromatin structure and function. This can involve covalent modification of histones, the incorporation of histone variants, and non-covalent remodelling by ATP-dependent remodeling enzymes. Histone post-translational modifications Since they were discovered in the mid-1960s, histone modifications have been predicted to affect transcription.[39] The fact that most of the early post-translational modifications found were concentrated within the tail extensions that protrude from the nucleosome core lead to two main theories regarding the mechanism of histone modification. The first of the theories suggested that they may affect electrostatic interactions between the histone tails and DNA to "loosen" chromatin structure. Later it was proposed that combinations of these modifications may create binding epitopes with which to recruit other proteins.[40] Recently, given that more modifications have been found in the structured regions of histones, it has been put forward that these modifications may affect histone-DNA[41] and histone-histone[42] interactions within the nucleosome core. Modifications (such as acetylation or phosphorylation) that lower the charge of the globular histone core are predicted to "loosen" core-DNA association; the strength of the effect depends on location of the modification within the core.[43] Some modifications have been shown to be correlated with gene silencing; others seem to be correlated with gene activation. Common modifications include acetylation, methylation, or ubiquitination of lysine; methylation of arginine; and phosphorylation of serine. The information stored in this way is considered epigenetic, since it is not encoded in the DNA but is still inherited to daughter cells. The maintenance of a repressed or activated status of a gene is often necessary for cellular differentiation.[18] Histone variants Although histones are remarkably conserved throughout evolution, several variant forms have been identified. It is interesting to note that this diversification of histone function is restricted to H2A and H3, with H2B and H4 being mostly invariant. H2A can be replaced by H2AZ (which leads to reduced nucleosome stability) or H2AX (which is associated with DNA repair and T cell differentiation), whereas the inactive X chromosomes in mammals are enriched in macroH2A. H3 can be replaced by H3.3 (which correlates with activate genes and regulatory elements) and in centromeres H3 is replaced by CENPA.[18] ATP-dependent nucleosome remodeling A number of distinct reactions are associated with the term ATP-dependent chromatin remodeling. Remodeling enzymes have been shown to slide nucleosomes along DNA,[44] disrupt histone-DNA contacts to the extent of destabilising the H2A/H2B dimer[45][46] and to generate negative superhelical torsion in DNA and chromatin.[47] Recently, the Swr1 remodeling enzyme has been shown to introduce the variant histone H2A.Z into nucleosomes.[48] At present, it is not clear if all of these represent distinct reactions or merely alternative outcomes of a common mechanism. What is shared between all, and indeed the hallmark of ATP-dependent chromatin remodeling, is that they all result in altered DNA accessibility. Studies looking at gene activation in vivo[49] and, more astonishingly, remodelling in vitro[50] have revealed that chromatin remodeling events and transcription-factor binding are cyclical and periodic in nature. While the consequences of this for the reaction mechanism of chromatin remodeling are not known, the dynamic nature of the system may allow it to respond faster to external stimuli. Source of the article published in description is Wikipedia. I am sharing their material. © by original content developers of Wikipedia. Link- http://en.wikipedia.org/wiki/Main_Page Material source: Molecular Biology of the Gene (4th Edition) James D. Watson (Author), Alan M. Weiner (Author), Nancy H. Hopkins (Author) Link: http://www.amazon.com/Molecular-Biology-Gene-4th-Edition/dp/0805396144
Views: 19863 Shomu's Biology
Operons and gene regulation in bacteria
 
10:10
Looking at how regulatory DNA sequences can repress or promote gene transcription (particularly in bacteria operons).
Views: 160330 Khan Academy
Mod-03 Lec-07 Role of chromatin in eukaryotic gene regulation
 
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Eukaryotic Gene Expression:Basics & Benefits by Prof.P N RANGARAJAN,Department of Biochemistry,IISC Bangalore. For more details on NPTEL visit http://nptel.iitm.ac.in
Views: 4282 nptelhrd
Epigenetics
 
09:21
Paul Andersen explains the concepts of genetics. He starts with a brief discussion of the nature vs. nurture debate and shows how epigenetics blurs this distinction. He explains how differentiation of cell types results from the inactivation of certain genes. He describes the three processes of epigenetics: DNA methylation, Histone acteylation and microRNA. Intro Music Atribution Title: I4dsong_loop_main.wav Artist: CosmicD Link to sound: http://www.freesound.org/people/CosmicD/sounds/72556/ Creative Commons Atribution License All images are either Public Domain or Creative Commons Attribution Licenses: "File:DNA Methylation.jpg." Wikipedia, the Free Encyclopedia. Accessed March 2, 2013. http://en.wikipedia.org/wiki/File:DNA_methylation.jpg. "File:Earrr.JPG." Wikipedia, the Free Encyclopedia. Accessed March 1, 2013. http://en.wikipedia.org/wiki/File:Earrr.JPG. "File:Epigenetic Mechanisms.jpg." Wikipedia, the Free Encyclopedia. Accessed March 3, 2013. http://en.wikipedia.org/wiki/File:Epigenetic_mechanisms.jpg. "File:Hela Cells Image 3709-PH.jpg." Wikipedia, the Free Encyclopedia. Accessed March 2, 2013. http://en.wikipedia.org/wiki/File:Hela_Cells_Image_3709-PH.jpg. "File:HeLa Cells Stained with Hoechst 33258.jpg." Wikipedia, the Free Encyclopedia. Accessed March 2, 2013. http://en.wikipedia.org/wiki/File:HeLa_cells_stained_with_Hoechst_33258.jpg. "File:MiRNA.svg." Wikipedia, the Free Encyclopedia. Accessed March 3, 2013. http://en.wikipedia.org/wiki/File:MiRNA.svg. GM, Cooper. English: Histone Acetylation, January 13, 2013. Cooper GM. The Cell: A Molecular Approach. 2nd edition. Sunderland (MA): Sinauer Associates; 2000. Regulation of Transcription in Eukaryotes. Available from: http://www.ncbi.nlm.nih.gov/books/NBK9904/. http://commons.wikimedia.org/wiki/File:Ch6f32.jpg. kumar35885. Simple DNA for Illustrations, n.d. http://openclipart.org/detail/58543/dna-by-kumar35885. Rosa, Gilberto Santa. Beautiful Lips., March 25, 2006. originally posted to Flickr as Lips ...............DSCF6115a_picnikbw/soft. http://commons.wikimedia.org/wiki/File:Beautiful_lips.jpg. SheLovesGhosts. Deutsch: Zentrale Heterochromie: Grüne Iris, Um Die Pupille Herum Jedoch Ein Braun-gelber Ring, March 5, 2009. Own work. http://commons.wikimedia.org/wiki/File:Iris_centralheterochromy.jpg.
Views: 186654 Bozeman Science
ATP dependent chromatin remodelling
 
07:07
This tutorial about chromatin remodeling explains the mechanism of ATP dependent chromatin remodeling and their importance in eukaryotic transcription regulation. For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html PPT source- Dr. Anindita Banerjee, Department of Microbiology, St. Xavier's college
Views: 6142 Shomu's Biology
Architecture, Assembly and Dynamics of Molecular Machines Regulating Eukaryotic Gene Transcription
 
01:06:40
Architecture, Assembly and Dynamics of Molecular Machines Regulating Eukaryotic Gene Transcription Air date: Wednesday, January 30, 2013, 3:00:00 PM Description: Wednesday Afternoon Lecture Series The regulation of gene expression is a complex task that is critical for the growth, development, and survival of organisms. Dr. Nogales' lecture will describe structural studies concerning protein complexes involved on epigenetic gene silencing and transcription initiation. Polycomb Repressive Complex 2 (PRC2) is essential for gene silencing, establishing transcriptional repression of specific genes by tri-methylating Lysine 27 of histone H3, which eventually results in the compaction of chromatin and the inaccessibility of genes to the transcriptional machinery. Dr. Nogales' group has obtained the first three-dimensional structure of the human PRC2 complex bound to its cofactor AEBP2 and localized all the PRC2 subunits and their functional domains, generating a detailed map of interactions. They show that regions in PRC2 that interact with modified histone tails are localized near the methyltransferase site, suggesting a molecular mechanism for the chromatin-based regulation of PRC2 activity. A highly regulated step in gene expression (in non-compacted chromatin) is the initiation of transcription by RNA polymerase II, which requires basal transcription factors known as TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH. These factors assemble sequentially onto the core promoters of protein coding genes to form a transcription pre-initiation complex following the initial recruitment of TFIID to core promoter DNA sequences. The size and scarcity of TFIID, typically purified from endogenous sources, are bottlenecks for structural studies. They have applied single-particle EM and extensive image-sorting methodologies to characterize the structural dynamics of human TFIID. We found a novel "rearranged" conformation of TFIID that corresponds to a high-affinity DNA binding state. Their studies suggest a model in which the distinct conformations of TFIID may serve as targets for transcription factors/cofactors to regulate the recruitment of TFIID to specific core promoters and the final transcriptional output. They have also used an in vitro reconstituted system to study the stepwise assembly of human TBP (substituting for TFIID), TFIIA, TFIIB, Pol II, TFIIF, TFIIE, and TFIIH onto promoter DNA using cryo-electron microscopy. Their structural analyses provide pseudo-atomic models at various stages of transcription initiation that illuminate critical molecular interactions for the proper loading of the transcription start site at the active center of Pol II. Author: Eva Nogales, Ph.D. University of California at Berkeley Runtime: 01:06:39 Permanent link: http://videocast.nih.gov/launch.asp?17779
Views: 2122 nihvcast
Chromatin remodelling and antisense-mediated up-regulation of the developmental switch gene
 
00:27
Chromatin remodelling and antisense-mediated up-regulation of the developmental switch gene eud-1 control predatory feeding plasticity. Vahan Serobyan et al (2016). Nature Communications http://dx.doi.org/10.1038/ncomms12337 Phenotypic plasticity has been suggested to act through developmental switches, but little is known about associated molecular mechanisms. In the nematode Pristionchus pacificus, the sulfatase eud-1 was identified as part of a developmental switch controlling mouth-form plasticity governing a predatory versus bacteriovorous mouth-form decision. Here we show that mutations in the conserved histone-acetyltransferase Ppa-lsy-12 and the methyl-binding-protein Ppa-mbd-2 mimic the eud-1 phenotype, resulting in the absence of one mouth-form. Mutations in both genes cause histone modification defects and reduced eud-1 expression. Surprisingly, Ppa-lsy-12 mutants also result in the down-regulation of an antisense-eud-1 RNA. eud-1 and antisense-eud-1 are co-expressed and further experiments suggest that antisense-eud-1 acts through eud-1 itself. Indeed, overexpression of the antisense-eud-1 RNA increases the eud-1-sensitive mouth-form and extends eud-1 expression. In contrast, this effect is absent in eud-1 mutants indicating that antisense-eud-1 positively regulates eud-1. Thus, chromatin remodelling and antisense-mediated up-regulation of eud-1 control feeding plasticity in Pristionchus.
Views: 6756 ScienceVio
Genome-wide association between transcription factor expression and chromatin accessibility...
 
06:10
...reveals chromatin state regulators - David Lamparter June 8, 2016 - ENCODE 2016: Research Applications and Users Meeting More: https://www.genome.gov/27566810
Enhancers and activators for eukaryotic gene regulation
 
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Enhancers and activators for eukaryotic gene regulation
Views: 30849 HeyNow1003

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